Early Stage Researcher in Bio2Brain Project (m/w/d) - MyBiotech
19th Ave New York, NY 95822, USA

Ausbildung zum/zur Chemielaborant/-in (m/w/d)

The advertised subproject will be carried out by a PhD student (“Early-stage Researcher”) at MyBiotech GmbH over a period of 36 months. The recruited researcher will work in the innovative drug formulations with an emphasis on industrial applicability of such production methods. The ESR will be registered for the PhD programme at University of Saarland Biopharmacy and Pharmaceutical Technology supervised by Prof. Dr. Marc Schneider.

The overall goal of this subproject is to develop pharmaceutically approved (bio)polymer based biopharmaceutic delivery systems with tailored transmucosal passage properties.

The specific goals are:

  • To develop nano- and/or micro-particles, which show enhanced drug delivery to brain and/or CNS via nasal administration using pharmaceutically approved formulation components ;
  • To establish standard operating procedures (SOP) for manufacturing ;
  • To characterize NPs and optimize NP preparation method to ensure safety and quality by adjusted process and formulation parameters
  • To evaluate drug loading and release properties at the site of action.

The main working tasks of the advertised subproject are:

  • Identification of effects of process parameters on the NP properties, drug release and BBB permeation.
  • Established SOPs for reproducible NP manufacturing, in-process controls and analytical methods
  • Determination of interdependency of particle qualities and process parameters on particle size, drug release and drug loading
  • Determination of interdependency of particle qualities and process parameters on particle size, drug release and drug loading

For more information please visit: https://bio2brain.eu/network/esrs/esr3-biopolymer-based-particulate-formulations-for-the-intranasal-transmucosal-delivery-of-biopharmaceuticals-myb/